T cell lymphocytes play a central role in the adaptive immune response. They are an essential tool of adoptive cell therapy for the treatment of chronic viral infections and malignant diseases.

Northwestern Medicine scientists have identified the cellular mechanisms that cause immune cells to differentiate and ultimately lose function during viral infection, findings that could improve ...

Using precise molecular techniques, including single-cell RNA sequencing, the team showed that this process is mediated in part by the effects of CD4 T cells on CD8 T cells – another subset of white ...

Researchers have identified a novel type of immune cell, called the stem-like CD4 T cell, that plays a pivotal role in anti-tumor immunity. The pre-clinical findings highlight the potential to ...

Researchers found that CD4+ T cells can be classified into 18 categories and 12 distinct gene programs, and that characteristic changes in CD4+ T cell profiles are associated with autoimmune disease, ...

Abnormal expansion of PD-1+ T lymphocytes may be a sign of lupus nephritis onset in patients with SLE. Elevated PD-1+CD4+ T cells represent an independent risk factor for lupus nephritis (LN) and may ...

The decrease in CD4 cells during HIV infection seems to be driven by immune activation, which does not always correlate with viral load. Experienced clinicians are all too familiar with the ...

Certain levels of urinary CD4+ T lymphocytes in patients with ANCA-associated vasculitis have a 60% and 98% sensitivity and specificity, respectively, for predicting future renal flares. Urinary CD4+ ...

Whole brain radiotherapy and intrathecal injection of thiotepa, combined with systemic treatment for the primary tumor, to treat solid tumor leptomeningeal metastasis: A prospective, single center, ...

Drug conjugates (ADCs) developed at Institute of Science Tokyo combine a CD4 mimic with neutralizing antibodies for enhanced suppression of human immunodeficiency virus (HIV) infection. By targeting ...