Researchers at Johannes Gutenberg University Mainz (JGU) in Germany and the Institute of Molecular Biology of Barcelona in Spain have discovered how the blood plasma protein fetuin-B binds to the ...

The new method centres on the principle of enzyme inhibition. Countless pharmaceuticals, ranging from antibiotics to chemotherapy drugs, work by blocking the action of enzymes, and the search for new ...

University of Illinois scientist Tim Garrow, in collaboration with Jiri Jiracek of the Czech Academy of Sciences, has applied for a provisional patent on a class of chemicals that has future ...

In our bones, specialized cells called osteoblasts are responsible for building up bone substance. A team of researchers led by scientists from the DKFZ-Hector Cancer Institute at the University ...

Targeting protein-protein interactions for a therapeutic purpose is an attractive idea that has proved to be extremely challenging in practice. This is due to the large and flat landscape of most ...

A potential new drug to treat the common cold prevents rhinoviruses and other picornaviruses from gaining a toehold in human cells, according to findings published in Nature Chemistry. Aurélie ...

A glycosyltransferase (GT) inhibitor with a novel mechanism of action could aid glycobiology research and drug discovery, according to a report in Nature Chemical Biology (DOI: 10.1038/nchembio.343).

Heparin is widely used as an anticoagulant, but evokes in some patients a potentially life-threatening condition called HIT. Clinical scientists at Ludwig-Maximilians-Universitaet (LMU) in Munich have ...

Accent Therapeutics has halted work on a solid tumor drug due to adverse events in a phase 1/2 study. | Accent Therapeutics has halted work on a solid tumor drug due to adverse events in a phase 1/2 ...

Scientists at Cambridge have demonstrated a new method for potentially fighting a form of leukemia, by targeting overactive enzymes that can lead to the disease. If the results of mice tests carry ...

In a new study published in Science Signaling titled, “Restoration of striatal neuroprotective pathways by kinase inhibitor treatment of Parkinson’s linked-LRRK2 mutant mice,” researchers from ...