For more than a century, Mendelian genetics has shaped how we think about inheritance: one gene, one trait. It is a model that still echoes through textbooks—and one that is increasingly reaching its ...

Mendelian (or, monogenic) disorders like sickle cell anaemia or cystic fibrosis occur due to mutations in a single gene. While there are currently over 7,000 known Mendelian disorders, many lack ...