In a recent study published in the Cell Reports journal, researchers assessed the impact of protein adduction on p53 tumor suppressor inhibition. Studies have shown that exposing esophageal cells to ...
Memorial Sloan Kettering Cancer Center investigators and collaborators have tested rezatapopt, an oral p53 reactivator ...
Pharmacogenomic trial of CPT-11-docetaxel in untreated patients (P) with advanced non small cell lung cancer (NSCLC). A phase II study of the Spanish Lung Cancer Group (SLCG). Correlation with the ...
Volume 11, Issue 25 of @Oncotarget reported that the present study was aimed at evaluating the hypothesis that p53 governs the expression and activation of the INSR gene in breast cancer cells. The ...
(Philadelphia, PA) – Researchers have known for a decade that the p53 tumor suppressor gene is important for killing cells as they proliferate under low-oxygen conditions inside tumors. As tumors grow ...
The results of research headed by a team in the lab of Michael Sigal, MD, at the Max Delbrück Center and Charité—Universitätsmedizin Berlin, have shed new light on the role of the p53 tumor suppressor ...
A long noncoding RNA (lncRNA), the RNA component of mitochondrial RNA-processing endoribonuclease (RMRP), was shown to promote the growth and proliferation of colorectal cancer (CRC) cells by ...
mRNA nanoparticles effectively and safely restored the function of the p53 tumor-suppressor gene in hepatocellular carcinoma models. When used in combination with immune checkpoint blockade, the mRNA ...
About half of all tumors have mutations of the gene p53, normally responsible for warding off cancer. Now, UT Southwestern scientists have discovered a new role for p53 in its fight against tumors: ...
About half of all tumors have mutations of the gene p53, normally responsible for warding off cancer. Now scientists have discovered a new role for p53 in its fight against tumors: preventing ...
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