Phosphorylation, a pivotal post‐translational modification, regulates a wide array of cellular processes by the covalent attachment of phosphate groups to proteins. This modification, largely executed ...

Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows the kinase to repeatedly modify its ...

Structurally, they look similar: MNK1 and MNK2 belong to the same enzyme family and are best known for regulating how cells ...

This study focused on how NMDAR, an important cell surface receptor, triggers a complex chemical cascade in postsynaptic neurons in the nucleus accumbens region of the brain. More specifically, the ...

Conventional small-molecule drugs for reducing pTau include phosphatase activators of PP2A, and kinase inhibitors of GSK3β, CDK5, etc., as well as active or passive immunotherapies targeting pTau.

A new study reveals that the twin enzymes MNK1 and MNK2 play distinct roles in the brain, with one governing memory and the other social behavior.

A protein’s life is anything but simple. Discover how transcription, translation, folding, modification, and degradation work together to preserve proteome integrity.