Diuretic therapy remains a vital cog in the management of hypertension; either as monotherapy or in combination with other antihypertensive classes. However, maximizing the antihypertensive effect of ...

The present investigation was conducted to determine how effective uricosuric agents were in preventing thiazide hyperuricemia and to what extent they might interfere with the diuretic action. With ...

Kidney stones affect nearly 10% of the global population. For more than three decades, thiazide diuretics, a common medication used for high blood pressure, have been the standard of care for kidney ...

Most accepted pharmacologic treatments for heart failure are supported by evidence from large clinical trials. In contrast, evidence from large, well-controlled clinical trials to guide the use of ...

In the chronic response phase of therapy the vasodepressor influence of a diuretic emerges as a process driven by a reduction in total peripheral resistance (TPR), which is inadequately explained ...