NFL Week 16 picks: Broncos edge Jaguars
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The 49ers' Week 16 matchup shifts as Colts QB Daniel Jones is lost for the season, impacting Indianapolis ahead of their meeting with San Francisco.
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49ers, Colts not ready to abandon division-title hopes
Having had an opportunity to watch division rivals attempt to hold serve in a tight playoff race, the San Francisco 49ers and Indianapolis Colts get a chance to help themselves on the field when they clash Monday night in Indianapolis.
A look at where the Jaguars stand in the AFC South and AFC standings through 15 weeks of the 2025 NFL regular season
It's now or never for the Indianapolis Colts when they defend home turf against the San Francisco 49ers on Monday night.
San Francisco 49ers superstar tight end George Kittle opens up about facing 44-year-old Indianapolis Colts quarterback Philip Rivers.
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NFL predictions: Playoff implications for 49ers vs. Colts on Monday Night Football from proven model
According to SportsLine's Inside the Lines team, Indianapolis on Monday night has much more to lose in Week 16
San Francisco would have a better chance at the No. 1 seed in the NFC playoffs if Seattle can pull off the victory at home.