Treatment-resistant depression complicates care, defying standard treatments, but new therapies are on the horizon, offering hope for more effective treatment options.

A study of depressed individuals found that an eight‐week treatment with selective serotonin reuptake inhibitors (SSRIs) reduced the activity of 5-HT4 receptors—a specific type of serotonin receptor—in the neostriatum region of the brain.

In his first Mental Elf blog, Tim van der Es discusses a Biological Psychiatry paper on the genetic relationship between ADHD & depression.

Fiancé star Larissa Dos Santos Lima has been diagnosed with major depressive disorder and is stepping away from social media. A rep for the reality star, 38, named Julia Dickson, announced the news on Larissa’s Instagram on Wednesday 19.

Ketamine can effectively treat depression, but whether depressed patients with alcohol use disorder can safely use ketamine repeatedly remains unclear clinically.

The following is a summary of “Spaced Transcranial Direct Current Stimulation for Major Depression,” published in the January 2025 issue of American Journal of Psychiatry by Couture et al. Researchers conducted a retrospective study on spaced transcranial direct current stimulation for major depressive disorder,

The depression treatment market is experiencing steady growth, driven by rising mental health awareness, increasing prevalence of depression, and advancements in novel therapies. The market is expanding with the introduction of innovative antidepressants,

The Royal Devon University Healthcare NHS Foundation Trust is leading ground-breaking clinical research that has the potential to transform treatments for neuropsychiatric disorders.

Major depressive disorder (MDD) is a leading cause of disability worldwide, with a significant proportion of patients (10-20%) progressing to treatment-resistant depression (TRD).

The following is a summary of “Comparative effectiveness of short-term psychodynamic psychotherapy and cognitive behavioral therapy for major depression in psychiatric outpatient clinics: a randomized controlled trial,

Objective This study aimed to investigate the incidence of overweight in patients with major depressive disorder (MDD) comorbid anxiety during the acute phase and to explore associated factors. Design Cross-sectional study.