Old Wisconsin's $125.3 million expansion in Sheboygan could bring up to $2.75 million in state tax credits and 75 new jobs.

In a potentially pivotal trial, PTC Therapeutics' experimental therapy for Huntington's disease (HD) met its primary endpoint, but questions about the data have raised doubts about the company's ...

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Aggregation of huntingtin protein with an expanded polyglutamine region is enhanced by its 17-residue N-terminal domain, which binds to itself and to the polyglutamine region. This enhancement is ...

Huntington's disease is a hereditary neurodegenerative disorder caused by an autosomal dominant mutation. The hallmark symptom of Huntington's disease is the presence of progressive chorea (abnormal ...

Background Mouse embryonic fibroblasts (MEFs) have been isolated from the widely studied Huntington’s disease (HD) mouse models zQ175 and YAC128. zQ175 knock-in mice contain a mutated version of human ...