This study was supported by a British Academy/Leverhulme Small Grant (Reference no.: SRG23\231049). The author declares no other relevant affiliations or financial interests. Andrea Révész and Andreas ...

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Enlicitide decanoate, an oral proprotein convertase subtilisin–kexin type 9 (PCSK9) inhibitor, was shown to reduce low-density lipoprotein (LDL) cholesterol levels in a phase 2 trial; longer-term data ...

Menin inhibitors target the interaction between menin and the KMT2A complex, offering a breakthrough in treating acute leukemias with specific genetic mutations. Monotherapy with menin inhibitors ...

Mistakes, whether spoken or promised, are universal. The feeling of putting our foot in our mouth arises from a key executive function that our brain controls: stopping ourselves. However, the ...

Please provide your email address to receive an email when new articles are posted on . An oral PCSK9 inhibitor lowered LDL cholesterol by up to 60% and improved other lipid parameters at 24 weeks.

Incyte’s decision to scrap work on its BET inhibitor program has not surprised analysts, who pointed to safety concerns overshadowing the drug class. The biopharma, which markets Novartis-partnered ...

Panelists discuss how SGLT2 inhibitors evolved from diabetes medications to become foundational heart failure therapy with class I recommendations across the ejection fraction spectrum, providing ...

Novartis has scored the FDA’s approval for a second BTK inhibitor that’s for a non-cancer indication, teeing off a potential competition with Sanofi down the line. The FDA has blessed Novartis’ ...

From Santiago Ramón y Cajal’s hand came branches and whorls, spines and webs. Now-famous drawings by the neuroanatomist in the late 19th and early 20th centuries showed, for the first time, the ...

A meta-analysis showed no significant differences between JAK inhibitor use and TNF antagonist use in terms of the risk for serious infections or malignant neoplasms in patients with immune-mediated ...

Serotonin reuptake inhibitors (SRIs) are a class of drugs that affect the brain’s serotonin system, and doctors most commonly prescribe them as antidepressants. SRIs increase the levels of serotonin ...