Thorough lentivirus characterization is essential for generating the highest quality gene therapy. Traditional methods only look at one piece of the puzzle, require purified samples, and can take days ...

Lentivirus is a genus in the family of Retroviridae that is very suitable for remodeling into gene transfer vectors due to its stable transgene expression, the ability to reach the nuclei of the ...

Metachromatic leukodystrophy (MLD) is a rare genetic disorder caused by the deficiency of arylsulfatase A (ARSA) or its activator prosaposin (PSAP). This leads to the accumulation of sulfatides in the ...

The field of cell and gene therapy is rapidly growing. In particular, the use of lentiviruses in CAR-T applications is becoming of higher importance. Lentiviruses are enveloped viruses that are rather ...

The mechanism of the action of the small ruminant lentivirus, a type of virus in the same family as HIV and which infects sheep and goat species, has been studied in a new doctoral thesis.

Lentivirus genus represents a diverse, yet exceptionally cohesive group of retroviruses. Their influence on the health and general well-being of animals and humans alike has been enormous. Members of ...

Progressive cognitive declines are the main clinical symptoms of Alzheimer’s disease (AD). Cognitive impairment in AD is directly correlated with amyloid beta (Aβ)-mediated synaptic deficits. It is ...

During the virtual Bioprocessing Summit in August, Cytiva reported that its new filtration process has advantages compared to traditional centrifuge approaches for removing viruses from suspension ...

Through a recent agreement with Oxford Genetics, Aldevron will now be providing the plasmids necessary for lentivirus production to their customers, according to an announcement made last week at the ...

Lentiviral vectors remain a cornerstone in cell and gene therapy applications, offering high transduction efficiency and integration capability. However, achieving consistent recovery during ...